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KMID : 1094020060230040400
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Journal of Veterinary Clinics
2006 Volume.23 No. 4 p.400 ~ p.404
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Effect of Treatment with Transdermal Ketoprofen on Adjuvant-Induced Arthritis
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Shim Kyung-Mi
Kim Se-Eun
Bae Chun-Sik
Choi Seok-Hwa
Kang Seong-Soo
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Abstract
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This study demonstrates the anti-arthritic effect of topical application of ketoprofen gel containing N-methyl-2-pyrrolidone (NMP) in adjuvant arthritis therapy. Adjuvant arthritis was induced by a single injection of Freund’s complete adjuvant (FCA). Mature female Sprague-Dawley rats were designated to 3 groups such as control group, K10 group (ketoprofen 10 mg/rat), and NK10 group (ketoprofen 10 mg/rat containing NMP). The anti-arthritic activity of ketoprofen containing NMP was tested not only as to its capability to suppress the inflammatory edema, but also bone damage (X-ray score and regional bone uptake) of the hind paw in arthritis-induced rats. These results showed a higher efficacy of ketoprofen containing NMP than ketoprofen treatment in the adjuvant-induced arthritis. Ketoprofen containing NMP has good intrinsic characteristics for formulation in an efficacious anti-inflammatory topical application.
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KEYWORD
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Adjuvant arthritis, Ketoprofen, N-methyl-2-pyrrolidone, rat
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